Structure before
speculation.
Books, workbooks, and analytical tools applying mathematical systems thinking to cardiovascular physiology, portfolio stability, investor behavior, and health biomarker tracking.
The Mathematics of
the Living Body
Volume 1: Cardiovascular Physiology
A rigorous companion text that derives every equation in cardiovascular physiology from its molecular biology. Every chapter opens with named proteins and cellular mechanisms. Every equation is labelled: core principle, useful approximation, or known limit. Every worked example reports a range, not a single number.
Volume 2: Respiratory
& Renal Physiology
The Mathematics of the Living Body
Ventilation-perfusion matching, renal tubular transport, acid-base regulation, and the feedback architecture shared between lung and kidney.
Stoic Investing:
Stability Reflection Workbook
Companion to the annotated Meditations
18 modules in investor discipline, behavioral analysis, and the Stability Score framework. Behavioral reflection structured around a quantitative diagnostic. Not a journal — a system.
Stoic Investing:
Stability Under Market Stress
An annotated edition of Marcus Aurelius’s Meditations
18 parts covering drawdown discipline, noise and narrative, time horizon, and the Stability Score framework. Public domain text, original commentary.
The Algorithm
of Life
BioFlywheel Series
A mathematical systems framework that applies the governing algorithms of biological life — homeostasis, feedback control, and adaptive stability — to the design of a resilient financial and personal life. Structure over speculation, at every scale.
Stability Score
Calculator
Quantitative portfolio diagnostic
Input four portfolio parameters. Receive a Stability Score from 0 to 100 with structural diagnosis and indicated actions. Designed for quarterly recalibration.
Math-Optimized Life Dashboard
A quantitative health ledger for the long game
Track 18+ biomarkers — blood pressure, A1C, cholesterol, kidney, thyroid, and more — with a simple slope formula that tells you whether each metric is rising, falling, or stable. The same trend-slope logic used in computational biology, applied to your own labs.
DASH Diet
Math Planner
Quantitative compliance tracker for blood pressure control
Weekly compliance scorer with auto-slope. Tracks both sodium targets (2,300 mg & 1,500 mg) and both calorie plans (2,000 & 1,600 cal). Links diet compliance to blood pressure outcomes.
Diabetes Prevention
Tracker
NIH DPP lifestyle goal tracker with slope analysis
Tracks the two NIH DPP goals — 7% weight loss and 150 min/week activity — with auto-computed slopes. Includes the 16-week NIH Lifestyle Balance program session tracker.
Connected
Health
Mathematical frameworks for personal health optimization
Applies the quantitative systems thinking behind the BioFlywheel methodology to personal health — connecting biomarker trends, lifestyle inputs, and long-term outcomes through mathematical frameworks grounded in clinical evidence.
A structural diagnostic,
not a market call.
The Stability Score answers one question: how stable is the structure of this portfolio? It does not predict returns — it measures whether your portfolio is designed to hold through stress, or amplify it.
Four inputs, each scored 0–25, summed to 100. Recalculate quarterly.
Zachariah Sinkala Publishing is the applied mathematics imprint of Zachariah Sinkala — computational cancer biologist, mathematician, and author of The Mathematics of the Living Body series.
The BioFlywheel methodology originated in research on biological homeostasis and metastatic dormancy. It is now applied across three domains: cardiovascular physiology (the MLB book series), portfolio stability (the Stability Score and Stoic Investing line), and personal health biomarker analysis (the NIH-based health trackers). The slope methodology used in the health trackers is the same longitudinal trend analysis used in computational oncology.
All physiology content is grounded in peer-reviewed literature with landmark citations per chapter. All health products are grounded in NIH/NIDDK and NIH/NHLBI published clinical evidence. All finance products are grounded in quantitative risk frameworks. Nothing relies on hype, prediction, or speculation.
Anti-hype. Structure-first. Mathematical verification over speculation.